A large Colombian family that has suffered from early-onset Alzheimer’s disease for generations will serve as a valuable resource to researchers desperately seeking to discover treatments to prevent the disease altogether, according to an article in The New York Times.
The 5,000 members of the community mostly come from the Andes region of Antioquia, where over the years many have inherited a genetic mutation that guarantees they will develop Alzheimer’s. Intermarriage and large families within the community have spread the disease quickly.
Amongst the group, memories begin failing in sufferers in the 40’s, but for some, as early as 32. By age 47, full blown Alzheimer’s has developed.
According to research, the brain suffers damage once dementia has set in. Researchers hope that by administering treatment to individuals before the disease manifests will lead to potential breakthroughs to prevention. The Colombian family members who carry the mutation always develop the disease, and researchers can predict when, making them ideal test candidates.
Treatment will be designed to prevent memory loss and brain atrophy. Researchers will also study when Alzheimer’s begins, by testing younger people, and observe physical clues that precede symptoms. Scientists hope to begin treatment next year, though potential results are years away.
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